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Cinnamyl isobutyrate was found exclusively in watermelon (EG) flavored hookah tobacco at 9% and is routinely detected as a fragrance in cosmetic products for its characteristic fruity, slightly floral odor 37

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Mayer found that the 60 mg dose would actually correspond to an oral LD50 (the amount of a poisonous substance required to kill 50% of those exposed) of around 0.8 mg/kg, or considerably less than the values determined for laboratory animals, which range from 3.3 (mice) to more than 50 mg/kg (rats)

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110,111 Although NIX is recognized to play an irreplaceable role in various cellular processes, how and when NIX is activated in these processes remains to be elucidated